insulin resistance

noun

: reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes

Examples of insulin resistance in a Sentence

Recent Examples on the Web

Sedentary lifestyles: Lack of regular physical activity has been linked to obesity, insulin resistance and chronic inflammation, all of which can contribute to colorectal cancer. —Kailey Asetov, Miami Herald, 11 Mar. 2025

Sleep deprivation is also associated with insulin resistance, which can lead to diabetes mellitus and obesity. —Judy Stone, Forbes, 10 Mar. 2025

Besides mapping the brain’s aging trajectory, the researchers also identified neuronal insulin resistance as one of its key drivers. —Paul Smaglik, Discover Magazine, 5 Mar. 2025

Gary explained that disruptions in the endocrine system can trigger inflammation, leading to conditions like insulin resistance, polycystic ovary syndrome (PCOS), and autoimmune disorders, which are increasingly linked to cancer. —Josh Hammer, Newsweek, 15 Feb. 2025

Word History

First Known Use

1927, in the meaning defined above

Rhymes for insulin resistance

• magnetoresistance
• assistance
• consistence
• desistance
• existence
• insistence
• persistence
• subsistence
• coexistence
• nonexistence
• distance

Medical Definition

insulin resistance

noun

: reduced sensitivity to insulin by the body's insulin-dependent processes (as glucose uptake, lipolysis, and inhibition of glucose production by the liver) that results in decreased activity of these processes or an increase in insulin production or both and that is typical of type 2 diabetes but often occurs in the absence of diabetes